AANP Lightning Round Practice Test

SNRI medications work by blocking the reuptake of norepinephrine, increasing its availability in the brain. Venlafaxine is classified as an SNRI because it inhibits the transporters for both serotonin and norepinephrine, with NE reuptake inhibition becoming more pronounced at higher doses. This dual action on serotonin and norepinephrine distinguishes it from other options. Fluoxetine and sertraline are SSRIs, mainly blocking serotonin reuptake. Amitriptyline is a tricyclic antidepressant that blocks several transporters, including those for norepinephrine and serotonin, but it is not labeled an SNRI and carries a broader, more anticholinergic side‑effect profile.